Asymmetric Organocatalysis

by Benjamin List

Estimated delivery 3-12 business days

Format Hardcover

Condition Brand New

Description Kerstin Etzenbach-Effers, Albrecht Berkessel: Non-Covalent Organocatalysis Based on Hydrogen Bonding: Elucidation of Reaction Paths by Computational Methods.- Petri M. Pihko, Inkeri Majander, and Anniina Erkkilä: Enamine Catalysis.- Jennifer L. Moore, Tomislav Rovis: Lewis Base Catalysts 6: Carbene Catalysts.- Amal Ting, Jennifer M. Goss, Nolan T. McDougal, and Scott E. Schaus: Brønsted Base Catalysts.- O. Andrea Wong, Yian Shi: Chiral Ketone and Iminium Catalysts for Olefin Epoxidation.- Alan C. Spivey, Stellios Arseniyadis: Amine, Alcohol and Phosphine Catalysts for Acyl Transfer Reactions.- John B. Brazier, Nicholas C.O. Tomkinson: Lewis Base Catalysts 2 Secondary and Primary Amine Catalysts for Iminium Catalysis.- Oksana Sereda, Sobia Tabassum, and René Wilhelm: Lewis Acid Organocatalysts.- Daniela Kampen, Corinna M. Reisinger, and Benjamin List: Chiral Bronsted Acids for C Organocatalysis.

Publisher Description

As nucleophiles, simple alkenes are typically so unreactive that only highly active electrophiles, such as carbocations, peroxides, and halogens will react with them. For the generation of carbon-carbon bonds, milder methods will often be required. Fortunately, it is possible to increase the reactivity of alkene-type p-nucleophiles by introducing electron-donating substituents. Substitution of one H with an OH or OR gives an enol or a vinyl ether, which are already much better nucleophiles. Using nitrogen instead of oxygen, one obtains even better nucleophiles, enamines. Enamines are among the most reactive neutral carbon nucleophiles, exhibiting rates that are even comparable to some charged nucleophiles, such as enolates [1, 2]. Most enamines, unfortunately, are sensitive to hydrolysis. The parent enamine, N,N-dimethylvinylamine, has in fact been prepared [3], but appears to be uns- ble. Enamines of cyclic ketones and many aldehydes can readily be isolated, however [4-7].The instability of enamines might at first appear to diminish the utility of enamines as nucleophiles, but actually this property can be viewed as an added benefit: enamines can be readily and rapidly generated catalytically by using a suitable amine and a carbonyl compound. The condensation of aldehydes or ketones with amines initially affords an imine or iminium ion, which then rapidly loses a proton to afford the corresponding enamine (Scheme 1).

Details

  • ISBN 3642028144
  • ISBN-13 9783642028144
  • Title Asymmetric Organocatalysis
  • Author Benjamin List
  • Format Hardcover
  • Year 2010
  • Pages 460
  • Edition 12200th
  • Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
GE_Item_ID:137956182;

About Us

Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love!

Shipping & Delivery Times

Shipping is FREE to any address in USA.

Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated.

International deliveries will take 1-6 weeks.

NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations.

Returns

If you wish to return an item, please consult our Returns Policy as below:

Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted.

Returns must be postmarked within 4 business days of authorisation and must be in resellable condition.

Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit.

For purchases where a shipping charge was paid, there will be no refund of the original shipping charge.

Additional Questions

If you have any questions please feel free to Contact Us.