Preface. Contributors. Introduction (L.F.M. van Zutphen). Legislation an d animal experimentation (P.C.M. de Greeve, J. Hampson, L.F.M. van Zutph en). Biology and husbandry of laboratory animals (R. Havenaar, J.C. Meij er, D.B. Morton, J. Ritskes-Hoitinga, P. Zwart). Behaviour, stress and w ell-being (J.M. Koolhaas, V. Baumans, H.J.M. Blom, D. von Holst, P.J.A. Timmermans, P.R. Wiepkema). Standardization of animal experimentation (A .C. Beynen, K. Grtner, L.F.M. van Zutphen). Nutrition and experimental results (A.C. Beynen, M.E. Coates). Genetic standardization (L.F.M. van Zutphen, H.J. Hedrich, H.A. van Lith, J.B. Prins). Microbiological stand ardization (R. Boot, J.P. Koopman, I. Kunstl). Diseases of laboratory a nimals (J.E. van Dijk, H. van Herck, M.C. Bosland). Animal models (A.C. Beynen, J. Hau). Phases in an animal experiment (A.C. Beynen, M.F.W. Fes ting). Design of animal experiments (A.C. Beynen, M.F.W. Festing, M.A.J. van Montfort). Organization and management of animal experiments (A.E.J .M. van den Bogaard, R. Fosse, R.G.M. ten Berg, J.T.W.A. Strik). Recogni tion of pain and distress ((V. Baumans, P.F. Brain). Anaesthesia, analge