Gangbusters is a roleplaying game published by TSR, Inc. in 1982 that emulates gang crime in the 1920s during American Prohibition.

Gangbusters is set in the 1920s in the fictional Lakefront City located on the western shore of Lake Michigan, analogous to Chicago. Players take the roles of criminals, law enforcement professionals, or other characters (such as newspaper reporters) who investigate or oppose criminals. An emphasis is placed on the violent growth of organized crime during Prohibition. Political corruption is also a recurring theme.