Sigilyph has appeared in both the Pokémon anime series and a Pokémon movie. Sigilyph appeared in Pokémon the Movie: Black—Victini and Reshiram and White—Victini and Zekrom, where it was used by the character Damon. Sigilyph made its anime debut in Explorers of the Hero's Ruin! (Black & White series).

They never vary the route they fly, because their memories of guarding an ancient city remain steadfast. The guardians of an ancient city, they use their psychic power to attack enemies that invade their territory. Psychic power allows these Pokémon to fly. Some say they were the guardians of an ancient city. Others say they were the guardians' emissaries. A discovery was made in the desert where Sigilyph fly. The ruins of what may have been an ancient city were found beneath the sands.