For dissolving uric acid stones 

Presentation 

Manufacturer’s packs of 280 g granules To enable patients to manage their own treatment the following items are included in each pack of Uralyt-U: 

-Directions for use 

-Measurespoon (for 2.5 g of granules) 

-Chart for recording dosage and pH readings 

- Uralyt-U indicator paper (pH 5.2 - 7.4) for measuring urine pH. 

Composition 

1 measure spoonful of 2.5 g of granules contains: Potassium sodium hydrogen citrate (6:6:3:5) 2.4 g 

Mode of action 

Any increase in the amount of uric acid excreted in the urine may lead to the formation or uric acid stones. Such stones arise only in acid urine, and the solubility of uric acid can be increased by shifting urine pH towards the alkaline side. In this way any existing calculi can be dissolved and the formation of fresh stones can be prevented. Urine pH can be adjusted to the exact level required by regulating the dose of Uralyt-U. 

Uses 

- For dissolving uric acid stones and preventing the formation of fresh stones 

- As a supportive measure in the treatment of cystine stones and cystinuria 

- To alkalinize the urine during uricosuric treatment of cytostatic therapy 

- For symptomatic therapy in porphyria cutanea tarda. 

Dosage 

Condition:

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In ordinary circumstances a daily amount of 4measurespoonfuls (=10 g of granules) should be taken in three separate portions after meals: 1 measurespoonful in the early morning, 1 at midday and 2 in the evening. 

The granules should be dissolved in a glass of water and drunk. 

The pH reading of the fresh urine should be kept within the following pH ranges: 

- Uric acid stones and uricosuric therapy: pH 6.2 - 6.8 

-Cystine stones: pH 7.5 - 8.5 

-Cytostatic therapy: at least pH 7 

-Porphyria cutanea tarda: pH 7.2 - 7.5 

-If the pH is below the stated range the evening dose should be raised by half a measurespoonful. 

-If the pH is above the stated range the evening dose should be lowered by half a measurespoonful. 

-When the pH of fresh urine tested before taking Uralyt-U is consistently within the stated range, patient and physician can be confident that the correct dose has been found. 

Measurement of urine pH. 

Immediately before taking each dose, one test strip from the block of indicator paper included in the pack should be moistened with fresh urine. For this purpose it should be held in the clip supplied. The moist test strip is then matched with the colour table and the corresponding pH is read off. The pH reading and the number of measurespoonfuls of granules taken each day must be entered on the chart. The patient should bring the chart every time he visits the doctor. The indicator paper supplied with the pack is not suitable for checking urine pH during treatment of cystine stones or porphyria cutanea tarda. For this purpose the physician can prescribe special indicator paper covering the range pH 7.2 - 9.7. The chart supplied with the pack can be used provided that the pH readings (colour numbers) at the head of the column are appropriately altered. 

Dosage and administration 

-As a general rule, initial dosage should be regulated under medical supervision to meet individual needs. 

-In principle, the dose of Uralyt-U should be governed by its effect. This means that urine pH should be measured before each dose, so that the correct dose can be chosen. The measure spoon supplied with the pack enables the necessary dose to be measured with sufficient accuracy. 

Duration of administration How long should treatment continue? The answer differs from case to case. The time required for complete dissolution of pure uric acid stones averages from 5 - 12 weeks. Neutralization of the urine with Uralyt-U should be continued for at least 3 months after the stones have been completely dissolved so as to prevent early recurrence. 

Interactions with other drugs 

If the patient is concurrently taking digitalis, the physician must bear in mind that the normal daily dose of Uralyt-U (10 g of granules) contains approximately 1.75 g (44.8mmol) of potassium.When prescribing a low sodium diet the physician should remember that the normal daily dose of Uralyt-U contains approximately 1 g (43.5mmol) of sodium. 

Side effects 

No side-effects have so far been reported.