- 4× NBA champion (2012, 2013, 2016, 2020)
- 4× NBA Finals MVP (2012, 2013, 2016, 2020)
- 4× NBA Most Valuable Player (2009, 2010, 2012, 2013)
- NBA In-Season Tournament champion (2023)
- NBA In-Season Tournament MVP (2023)
- 20× NBA All-Star (2005–2024)
- 3× NBA All-Star Game MVP (2006, 2008, 2018)
- 13× All-NBA First Team (2006, 2008–2018, 2020)
- 3× All-NBA Second Team (2005, 2007, 2021)
- 3× All-NBA Third Team (2019, 2022, 2023)
- 5× NBA All-Defensive First Team (2009–2013)
- NBA All-Defensive Second Team (2014)
- NBA Rookie of the Year (2004)
- NBA All-Rookie First Team (2004)
- NBA scoring champion (2008)
- NBA assists leader (2020)
- NBA 75th Anniversary Team
- AP Athlete of the Decade (2010s)
- 4× AP Athlete of the Year (2013, 2016, 2018, 2020)
- 3× Sports Illustrated Sportsperson of the Year (2012, 2016, 2020)
- USA Basketball Male Athlete of the Year (2012)
- 2× National high school player of the year (2002, 2003)
- McDonald's All-American Game MVP (2003)
- 2× First-team Parade All-American (2002, 2003)
- 3× Ohio Mr. Basketball (2001–2003)
- 3x USA Today All-USA First Team (2001–2003)
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