Era: The image is a "linen" postcard, a style of postcard that was popular from the 1930s to the 1945s.
Location: The perspective captures a busy downtown street, the waterfront, and across the bay to Coronado and Point Loma in the background.
Key Buildings/Features: Several historical buildings are visible, and the scene includes cars from the era on the street and ships in the harbor. Historic buildings that might be present in views like this include the U.S. Grant Hotel and the former Pickwick Hotel (now The Sofia Hotel