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Based on the real-life experiences of writers Shaun Pye and Sarah Crawford, whose daughter was born with an extremely rare chromosomal disorder, There She Goes follows the day-to-day life of Rosie Yates (Miley Locke), a severely learning disabled girl and her family, dad Simon (David Tennant), mum Emily (Jessica Hynes) and older brother Ben (Edan Hayhurst). '414' - The family struggles as Rosie hits puberty. She becomes increasingly erratic, before, out of the blue, her genetic condition is diagnosed and Si and Em come to terms with why Rosie is Rosie.