On February 10, 1949, the Albany to Tri-Cities to Elmira / Corning to Ithaca service, which had been inaugurated on November 8, was extended from Ithaca to Syracuse; thus, Syracuse made its inaugural southbound dispatch via this service. 

Douglas DC-3 aircraft were utilized. 

This cover was carried on the inaugural Air Mail Route 94 flight from Syracuse, New York to Elmira, New York, New York (where it was backstamped) and is listed in the Contract Air Mail Flights (CAM) section of The American Air Mail Catalogue as 94S16.

Perry Nahl, a former Editor-in-Chief of The American Air Mail Catalogue, prepared the cover.

A change in ownership prompted the airline to rename itself Mohawk Airlines on August 23, 1952.  

On April 12, 1972, the Civil Aeronautics Board approved the merger of Mohawk Airlines with Allegheny Airlines, with Allegheny Airlines (later renamed USAir and US Airways) as the surviving company. The takeover was completed by June 1, 1972.

US Airways was a major American airline that ceased operating independently when the Federal Aviation Administration granted a single operating certificate to US Airways and American Airlines on April 8, 2015.