Joséphine-Charlotte met Jean, Grand Duke of Luxembourg during one of her short stays with her godmother and future mother-in-law, Grand Duchess Charlotte, in Fischbach in 1948.[4] Rumours of the engagement of Joséphine-Charlotte and Jean had already been circulating after Jean visited her in Pregny-Chambésy in 1948.[2] On 7 November 1952, the couple announced their engagement to the public.[2] Joséphine-Charlotte and Jean were joined in marriage on 9 April 1953 in Luxembourg.[3] During their 52-year marriage, the couple had five children:[1]

Princess Marie-Astrid of Luxembourg (b. 17 February 1954)

Henri, Grand Duke of Luxembourg (b. 16 April 1955)

Prince Jean of Luxembourg (b. 15 May 1957)

Princess Margaretha of Luxembourg (b. 15 May 1957)

Prince Guillaume of Luxembourg (b. 1 May 1963)