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Alice James (August 7, 1848 – March 6, 1892) was an American diarist, and the younger sister of novelist Henry James and philosopher and psychologist William James. Her relationship with William was unusually close, and she seems to have been badly affected by his marriage. James suffered lifelong health problems that were generally dismissed as hysteria in the style of the day. She is best known for her published diaries.
As Alice was suffering from breast cancer, which she died from in London in 1892 at age 43, her brother William James wrote her a letter explaining how much he pitied her. He advised her to "look for the little good in each day as if life were to last a hundred years." He wanted her to save herself from suffering the torment of physical pain. "Take all the morphia (or other forms of opium if that disagrees) you want, and don't be afraid of becoming an opium-drunkard. What was opium created for except for such times as this?"