This 2021 Chicago White Sox Topps baseball team set contains the following:
| 14 | Do It for the Fans! | Combo |
| 23 | Nomar Mazara | |
| 69 | Gio Gonzalez | |
| 89 | Lucas Giolito | |
| 138 | Tim Anderson | |
| 180 | Jose Abreu | LL |
| 197 | Nick Madrigal | Rookie |
| 223 | Luis Robert | Rookie Cup |
| 231 | Dane Dunning | Rookie |
| 279 | Danny Mendick | |
| 284 | Eloy Jimenez | |
| 294 | Leury Garcia | |
| 311 | Codi Heuer | Rookie |
| 318 | Team | Team Card |
| 331 | Jose Abreu | |
| 337 | Jarrod Dyson | |
| 362 | Garrett Crochet | Rookie |
| 407 | Steve Cishek | |
| 426 | Matt Foster | Rookie |
| 435 | Dylan Cease | Future Stars |
| 483 | Zack Burdi | Rookie |
| 486 | South Side Strength | Combo Card |
| 488 | Dallas Keuchel | |
| 520 | Yoan Moncada | |
| 524 | Yasmani Grandal | |
| 528 | Jonathan Stiever | Rookie |
| 554 | Adam Eaton | |
| 559 | Edwin Encarnacion |