In the first film, a group of six individuals are stalked by One Eye, Saw Tooth, and Three Finger. Chris Flynn (Desmond Harrington) is forced to make a detour after a chemical spill on the road. He makes a wrong turn and crashes into another vehicle which had already fallen victim to one of the family's road traps. While searching for help in the cabin belonging to the three monstrous mountain men, they are hunted down one by one. At the end, Chris and Jessie Burlingame (Eliza Dushku) survive.

Wrong Turn 2: Dead End (2007)

The second film introduces a larger family of cannibals: Ma, Pa, Brother and Sister. Three Finger and the Old Man are the only returning characters from the first film. This time, the cannibals hunt down a group of reality show contestants who are taking part in a survival reality tv show.

Wrong Turn 3: Left for Dead (2009)

Wrong Turn 3: Left for Dead features a group of prison officers and convicts. The returning character Three Finger causes the transport bus to crash, allowing the convicts to escape and take the surviving prison officers, Nate (Tom Frederic) and Walter (Chucky Venn) prisoner. While fleeing, the convicts and their prisoners stumble across a lost truck which had been transporting thousands of dollars, as well as Alex Miles (Janet Montgomery), who has been lost in the woods since Three Finger killed the rest of her friends. Eventually, Three Toes (Three Finger's nephew) is killed by Chavez. Three Finger finds Three Toes's severed head, which makes him furious. He creates a shrine and leaves the head on display in his cabin. The one surviving convict, Brandon, convinces Nate of his innocence, and is set free. A greedy Nate returns to the truck to steal the money that Chavez wanted. But Brandon shoots him in the back with a bow and arrow and takes the money for himself. An unknown cannibal comes up behind Brandon and bludgeons him with a crude club killing him and leaving Alex the only survivor in the film.

Wrong Turn 4: Bloody Beginnings (2011)

This film provides the back story to the three original killers and shows their childhood. It also shows how the three brothers and several others escaped. The story focuses on a group of nine teenagers who take a wrong turn while riding their snowmobiles looking for their cabin. They end up in an old abandoned insane asylum which is still inhabited by Three Finger, Saw Tooth and One Eye. The friends decide to spend the night in the asylum and they are attacked by the three brothers. By the end of the film, all nine teenagers are dead. The film served as a prequel to the first film.

Wrong Turn 5: Bloodlines (2012)

It is revealed that Maynard is a serial killer who has been on the run for over thirty years, and is now in cahoots with the three cannibal brothers. He repeatedly refers to them as 'my boys' and his kin. Throughout the course of the film, the brothers attempt to break Maynard out of jail and kill off the college students and Sheriff Angela Carter (Camilla Arfwedson), while the rest of the town is at the festival. The film ends with Maynard and the three brothers escaping with the blinded Lita (Roxanne McKee) as a captive.

This film is a sequel to Bloody Beginnings and leading the events of Wrong Turn (2003).

Wrong Turn 6: Last Resort (2014)

In the sixth installment, Danny (Anthony Ilott) discovers his long lost family as he takes his friends to Hobb Springs, a Forgotten resort deep into West Virginia Hills. Danny then has to choose between his family or his friends as they are being killed by his family one by one.

Wrong Turn (2021)

Internationally known as Wrong Turn: The Foundation, the reboot follows six friends hiking on the Appalachian Trail who become hunted by the Foundation when they inadvertently intrude on the community's land.