The Silence of the Lambs (1991) features a renowned cast anchored by the performances of the two actors you mentioned, alongside several other key figures:

• Jodie Foster as Clarice Starling: A young, ambitious FBI trainee who is assigned to interview a brilliant, incarcerated cannibalistic serial killer to gain insight into another active serial killer.

• Anthony Hopkins as Dr. Hannibal Lecter: A former psychiatrist and highly intelligent, manipulative serial killer who agrees to help Clarice in exchange for glimpses into her own past.

This psychological thriller is one of the few films to win the "Big Five" Academy Awards (Best Picture, Best Director, Best Actor, Best Actress, and Best Adapted Screenplay).