Category | Details |
|---|---|
Type | Straight dip/immersion fiber optic probe for UV-Vis absorbance measurements. Supports reflection mode with interchangeable tips. |
Optical Path Lengths | Interchangeable tips: Path length determines sensitivity and linear range for absorbance. Note: comes with 20mm tip installed - NO OTHER TIPS AVAILABLE |
Wavelength Range | Optimal: 240–500 nm (Deuterium lamp source). UV cutoff around 240 nm due to transmission losses; consistent performance from 250–314 nm, with potential variability below 240 nm. |
Absorbance Range | Up to 2 AU (absorbance units). Linear range: 0.05–1.5 AU across path lengths (deviation above 1.5 AU, e.g., ~11% at 2.0 AU for 20 mm path). Limit of Quantitation (LOQ): ~0.03 AU without excipients, ~0.05 AU with insoluble excipients. |
Performance Metrics | - Baseline flatness: ≤0.002 AU (240–600 nm)
- Noise: ≤0.002 AU at 600 nm
- Stability: ≤0.002 AU at 270 nm
- Stray light: ≤1%
- Wavelength accuracy: ±1 nm (UV), ±2 nm (visible)
- Minimum sampling interval: 2 seconds
- Precision: RSD ~1–6% per probe, ~3.37% across multiple probes (tested with hydralazine HCl standards). |
Materials and Design | - Optical components: Quartz or similar fibers for UV transmission; internal mirrors for light reflection.
- Tip: Likely stainless steel or compatible material for immersion in dissolution media (e.g., acids, buffers).
- Cable: Gray protective sheathing (PVC or silicone jacket), bifurcated design with two connectors (typically SMA or FC type; one often color-coded, e.g., blue for identification).
- Compatibility: Resistant to common excipients; handles scattering from insoluble particles (e.g., starch, crospovidone) via baseline correction (e.g., at 380 nm). Avoids significant Tyndall scattering in tested conditions. |
Dimensions | Probe-specific dimensions not explicitly detailed in sources, but compatible with standard dissolution vessels:
- Fits USP Apparatus II (paddle stirrers at 50 rpm).
- Recommended standardization containers: ≥25 mm internal diameter (e.g., 20-mL scintillation vials).
- System-level dimensions (Rainbow R6 unit): 275 mm H × 177 mm W × 436 mm D. Probe cable length estimated at 2m. |
Compatibility | Integrates with Rainbow R6 monitor and various dissolution testers (e.g., MicroDISS: 2–5 mL min. media; MiniDISS: 40–100 mL; MacroFLUX: 800–900 mL). |