Carlisle, Mellick & Co. was a significant Wall Street brokerage firm founded in 1908, known for its specialization in "odd lot" trades, which involved smaller quantities of stock than the standard 100-share lots. The firm operated during a particularly volatile period in U.S. financial history, including the 1929 stock market crash. During the aftermath of the crash, the company’s office was notably one of the busiest, clearing transactions and coping with the market’s collapse.

The firm was deeply embedded in the New York Stock Exchange community and was influential in trading practices of the era. One of its prominent partners was Jay F. Carlisle, who played a key role in New York's financial circles until his passing in 1937. Carlisle, Mellick & Co. continued to be an important player in the financial sector during the early 20th century.