Science Magazine - One Issue 

6 December 2024

Programmed T Cells. Targeting the brain and other tissues to treat cancer and inflammation

How the Ukraine war breeds unstoppable infections

Total shark and ray abundance halved since 1970

Policies to reduce global plastic waste

Pages 1065-1184

COVER An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions.

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