Gamers once again join American lawyer Kate Walker for an atmospheric third-person adventure in Syberia 3. The story begins after Walker has departed the titular island of Syberia, where relatives of mammoths still roam, and mysteriously ends up nearly dead on the edge of a river. She is rescued by members of the Youkol tribe, and gamers must help her collect and combine items, solve puzzles, aid the Youkol people in their ancient traditions, and deal with adversaries from her past adventures.