Isabella was the elder daughter of King Ferdinand VII and Queen Maria Christina. Shortly before Isabella's birth, her father issued the Pragmatic Sanction to revert the Salic Law and ensure the succession of his firstborn daughter, due to his lack of a son. She came to the throne a month before her third birthday, but her succession was disputed by her uncle Infante Carlos (founder of the Carlist movement), whose refusal to recognize a female sovereign led to the Carlist Wars. Under the regency of her mother, Spain transitioned from an absolute monarchy to a constitutional monarchy, adopting the Royal Statute of 1834 and Constitution of 1837.

Isabella was declared of age and began her personal rule in 1843. Her effective reign was a period marked by palace intrigues, back-stairs and antechamber influences, barracks conspiracies, and military pronunciamientos. Her marriage to Francisco de Asís, Duke of Cádiz was an unhappy one, and her personal conduct as well as rumours of affairs damaged her reputation. In September 1868, a naval mutiny began in Cadiz, marking the beginning of the Glorious Revolution. The defeat of her forces by Marshal Francisco Serrano, 1st Duke of la Torre, brought her reign to an end, and she went into exile in France. In 1870, she formally abdicated the Spanish throne in favour of her son, Alfonso. In 1874, the First Spanish Republic was overthrown in a coup. The Bourbon monarchy was restored, and Alfonso ascended the throne as King Alfonso XII. Isabella returned to Spain two years later but soon again left for France, where she resided until her death in 1904.

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