The Amazing Spider-Man #381 is a comic book released in September 1993, published by Marvel Comics. The story features characters from the Spider-Man universe, including Spider-Man himself, Hulk, Aunt May, Mary Jane Watson Parker, and Doc Samson. The comic book belongs to the tradition of US Comics, and is part of the series The Amazing Spider-Man. The fabulous cover art is by Randy Emberlin and Mark Bagley.

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