Tumor markers are substances found in the human body, usually in blood, urine or body tissues that can be elevated in cancer. So, they are biochemical indicators of the presence of a tumor. We can detect specific cancer by various laboratory techniques & provide therapeutic benefit to the patient. With advances in technology, researchers are more inclined towards genomics, proteomics, serum biomarkers, salivary markers etc. to detect tumor or malignancy at the earliest. Thus, this book briefly comprises of tumor markers of common systemic, oral & paraoral malignancies with their laboratory techniques and recent advancements which thereby greatly promote progress towards novel diagnostic & predictive tools for early detection of cancer. This book is very useful for students in medical, dental, researchers and professionals.