Fully compatible with these games/platforms:

PC: Clone Hero, YARG, etc.

PS3: All Guitar Hero/Rock Band Games + other guitar hero-like games.

PS4/5: Compatible with Rock Band 4 + upcoming Guitar Hero-like games. (Stage Tour)

Xbox 360: All Guitar Hero/Rock Band Games + other guitar hero-like games.

Compatibility with other platforms:

Wii: Guitar Hero games require nunchuck emulation, Rock Band requires to be set as a Rock Band Guitar in Santroller.

Xbox One/Series Consoles: Requires an official Xbox Controller to be connected to the USB port for authenticating
Then it is functional on Rock Band 4 + upcoming Guitar Hero-like games. (Stage Tour)

Fortnite Festival: Requires Start Button to be held while plugging it in, then it is detected as a Keyboard. (Ideal to still have a controller connected to the console for movement in menus and the lobby)