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"House" (also known as "House, M.D." and "Dr. House" in some international markets) is an American medical drama television series created by David Shore for Fox. It aired for eight seasons from November 16, 2004 to May 21, 2012. It focuses on Dr. Gregory House (Hugh Laurie), an unconventional and misanthropic medical genius who, despite his dependence on pain medication, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital (PPTH) in New Jersey. He often clashes with his fellow physicians, including his own diagnostic team, as his hypotheses about patients' illnesses are often based on subtle or controversial insights, and his flouting of hospital rules and procedures frequently leads him into conflict with his boss, hospital administrator and Dean of Medicine Dr. Lisa Cuddy (Lisa Edelstein). House's only true friend is Dr. James Wilson (Robert Sean Leonard), head of the Department of Oncology.

During the first three seasons, House's diagnostic team consists of Dr. Robert Chase (Jesse Spencer), Dr. Allison Cameron (Jennifer Morrison), and Dr. Eric Foreman (Omar Epps). At the end of the third season, this team disbands. Rejoined by Foreman, House gradually selects three new team members: Dr. Remy "Thirteen" Hadley (Olivia Wilde), Dr. Chris Taub (Peter Jacobson), and Dr. Lawrence Kutner (Kal Penn). Chase and Cameron continue to appear occasionally in different roles at the hospital. Kutner dies late in season five; early in season six, Cameron departs the hospital, and Chase returns to the diagnostic team. Thirteen takes a leave of absence for most of season seven, and her position is filled by medical student Martha M. Masters (Amber Tamblyn). Cuddy and Masters depart before season eight; Foreman becomes the new Dean of Medicine, while Dr. Jessica Adams (Odette Annable) and Dr. Chi Park (Lo Mutuc) join House's team.

"House" was among the top 10 series in the United States from its second through fourth seasons. Distributed to 71 countries, it was the most-watched TV program in the world in 2008. It received numerous awards, including five Primetime Emmy Awards, two Golden Globe Awards, a Peabody Award, and nine People's Choice Awards. On February 8, 2012 Fox announced that the eighth season would be its last. The series finale aired on May 21, 2012 following an hour-long retrospective.