William
Nunn Lipscomb Jr. (December
9, 1919 – April 14, 2011) was a Nobel Prize-winning American inorganic and organic chemist working in nuclear magnetic resonance, theoretical chemistry, boron chemistry,
and biochemistry. Lipscomb was
born in Cleveland, Ohio. His family moved to Lexington, Kentucky in
1920, and he lived there until he received his Bachelor of Science degree in Chemistry at the University of Kentucky in
1941. He went on to earn his Doctor of Philosophy degree
in Chemistry from the California Institute of
Technology (Caltech) in 1946. From 1946 to 1959 he taught at
the University of Minnesota.
From 1959 to 1990 he was a professor of chemistry at Harvard University, where
he was a professor emeritus since
1990. Lipscomb was married to the former Mary Adele Sargent from 1944 to 1983. They
had three children, one of whom lived only a few hours. He married Jean Evans
in 1983. They had one adopted daughter. Lipscomb resided in Cambridge, Massachusetts until
his death in 2011 from pneumonia. "My early home environment
... stressed personal responsibility and self reliance. Independence was
encouraged especially in the early years when my mother taught music and when
my father's medical practice occupied most of his time." In grade school
Lipscomb collected animals, insects, pets, rocks, and minerals. Interest in
astronomy led him to visitor nights at the Observatory of the University of
Kentucky, where Prof. H. H. Downing gave him a copy of Baker's Astronomy. Lipscomb
credits gaining many intuitive physics concepts from this book and from his
conversations with Downing, who became Lipscomb's lifelong friend. The young
Lipscomb participated in other projects, such as Morse-coded messages over wires and crystal radio sets, with five nearby friends who became
physicists, physicians, and an engineer. At age of 12, Lipscomb was given a
small Gilbert chemistry set. He expanded
it by ordering apparatus and chemicals from suppliers and by using his father's
privilege as a physician to purchase chemicals at the local drugstore at a
discount. Lipscomb made his own fireworks and entertained visitors with color
changes, odors, and explosions. His mother questioned his home chemistry hobby
only once, when he attempted to isolate a large amount of urea from urine.
Lipscomb credits perusing the large medical texts in his physician father's
library and the influence of Linus Pauling years later to his undertaking biochemical
studies in his later years. Had Lipscomb become a physician like his father, he
would have been the fourth physician in a row along the Lipscomb male line. The
source for this subsection, except as noted, is Lipscomb's autobiographical
sketch. Lipscomb's high-school chemistry teacher, Frederick Jones, gave
Lipscomb his college books on organic, analytical, and general chemistry, and asked only that Lipscomb take the
examinations. During the class lectures, Lipscomb in the back of the classroom
did research that he thought was original (but he later found was not): the
preparation of hydrogen from sodium formate (or sodium oxalate) and sodium hydroxide. He took care to include gas analyses and to
search for probable side reactions. Lipscomb
later had a high-school physics course and took first prize in the state
contest on that subject. He also became very interested in special relativity. In
college at the University of Kentucky Lipscomb had a music scholarship. He
pursued independent study there, reading Dushman' s Elements of Quantum
Mechanics, the University of Pittsburgh Physics
Staff's An Outline of Atomic Physics, and Pauling's The
Nature of the Chemical Bond and the Structure of Molecules and Crystals. Prof.
Robert H. Baker suggested that Lipscomb research the direct preparation of
derivatives of alcohols from dilute aqueous solution without first separating the alcohol and
water, which led to Lipscomb's first publication.
For graduate school Lipscomb chose Caltech, which offered him a teaching
assistantship in Physics at $20/month. He turned down more money from Northwestern University,
which offered a research assistantship at $150/month. Columbia University rejected
Lipscomb's application in a letter written by Nobel prizewinner Prof. Harold Urey. At Caltech Lipscomb intended to study
theoretical quantum mechanics with
Prof. W. V. Houston in the
Physics Department, but after one semester switched to the Chemistry Department
under the influence of Prof. Linus Pauling. World War II work divided
Lipscomb's time in graduate school beyond his other thesis work, as he partly
analyzed smoke particle size, but mostly worked with nitroglycerin–nitrocellulose propellants, which involved handling vials
of pure nitroglycerin on many occasions. Brief audio clips by Lipscomb about
his war work may be found from the External Links section at the bottom of this page, past
the References. The source for this subsection, except as noted, is Lipscomb's
autobiographical sketch.