Title: Cell
Type: Medical Journal
Publisher: Cell Press / Cell Press Journals
Frequency: Bi-Weekly
Volume: 171
Issue Number: 6
Date Released: November 30, 2017

Features:
Table of Contents: Leading Edge

■ ■  SELECT ■ ■
■ ■  BENCHMARKS ■ ■
■ ■  STORIES ■ ■
  • 1236 ➥ As Time Flew By ➥ by M.W. Young
  • 1241 ➥ Life is an N of 1 ➥ by M. Rosbash
■ ■  CONVERSATIONS ■ ■
  • 1246 ➥  A Nobel Pursuit May Not Run like Clockwork
■ ■  PREVIEWS ■ ■
  • 1252 ➥ Tumor Evolution: A Problem of Histocompatibility ➥ by N.I. Vokes and E.M. Van Allen
  • 1254 ➥ Phytochromes: Where to Start? ➥ by S. Oh and B.L. Montgomery
  • 1256 ➥ Platelets, On Your Marks, Get Set, Mirgrate! ➥ by S.K. Bambach and T. Lammermann
■ ■  SNAPSHOT ■ ■
  • 1468 ➥ Circadian Clock ➥ by B.J. Song and D. Rogulja
■ ■  ARTICLES ■ ■
  • 1259 ➥ Allele-Specific HLA Loss and Immune Escape in Lung Cancer ➥ by N. McGranahan, R. Rosenthal, C.T. HIley, A.J. Rowan, T.B.K. Watkins, G.A. Wilson, N.J. Birkbak, S. Veeriah, P. Van Loo, J. Herrero, C. Swanton, and the TRACERx Consortium
  • 1272 ➥ MHC-I Genotype REstricts the Oncogenic Mutational Landscape ➥ by R. Marty, S. Kaabinejadian, D. Rossell, M.J. Slifker, J. van de Haar, H.B. Engin, N. de Prisco, T. Ideker, W.H. Hildebrand, J. Font-Burgada, and H. Carter
  • 1284 ➥ Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer ➥ M.J. Topper, M. Vaz, K.B. Chiappinelli, C.E.D. Shields, N. Niknafs, R.-W.C. Yen, A. Wenzel, J. Hicks, M. Ballew, M. Stone, P.T. Tran, C.A. Zahnow, M.D. Hellmann, V. Anagnostou, P.L. Strissel, R. Strick, V.E. Velculescu, and S.B. Baylin
  • 1301 ➥ Myc Cooperates with Ras by Programming Inflammation and Immune Suppression ➥ by R.M. Kortlever, N.M. Sodir, C.H. Wilson, D.L. Burkhart, L. Pellegrinet, L. Brown Swigart, T.D. Littlewood, and G.I. Evan
  • 1316 ➥ Light Controls Protein Localization through Phytochrome-Mediated Alternative Promoter Selection ➥ by T. Ushijima, K. Hanada, E. Gotoh, W. Yamori, Y. Kodama, H. Tanaka, M. Kusano, A. Fukushima, M. Tokizawa, Y.Y. Yamamoto, Y. Tada, Y. Suzuki, and T. Matsushita
  • 1326 ➥ Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases ➥ by J.M. Reitsma, X. Liu, K.M. Reichermeier, A. Moradian, M.J. Sweredoski, S. Hess, and R.J. Deshaies
  • 1340 ➥ An Unexpectedly Complex Architecture for Skin Pigmentation in Africans ➥ by A.R. Martin, M. Lin, J.M. Granka, J.W. Myrick, X.Liu, A. Sockell, E.G. Atkinson, C.J. Werely, M. Moller, M.S. Sandhu, D.M. Kingsley, E.G. Hoal, X. Liu, M.J. Daly, M.W. Feldman, C.R. Gignoux, C.D. Bustamante, and B.M. Hennn
  • 1354 ➥ Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance ➥ by E. Garcia-Fernandez, G. Koch, R.M. Wagner, A. Fekete, S.T. Stengel, J. Schneider, B. Mielich-Suss, S. Geibel, S.M. Markert, C. Stigloher, and D. Lopez
  • 1368 ➥ Migrating Platelets Are Mechano-scavengers that Collect and Budle Bacteria ➥ by F. Gaertner, Z. Ahmad, G. Rosenberger, S. Fan, L. Nicolai, B. Busch, G. Yavuz, M. Luckner, H. Ishikawa-Ankerhold, R. Hennel, A. Benechet, M. Lorenz, S. Chandraratne, I. Schubert, S. Helmer, B. Striednig, K. Stark, M. Janko, R.T. Bottcher, A. Verschoor, C. Leon, C. Gachet, T. GUdermann, M. Mederos y Schnitzler, Z. Pincus, M. Iannacone, R. Haas, G. Wanner, K. Lauber, M. Sixt, and S. Massberg
  • 1383 ➥ Epsin-Dependent Ligand Endocytosis Activates Notch by Force ➥ by P.D. Langridge and G. Struhl
  • 1397 ➥ Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores ➥ by A. Elosegui-Artola, I. Andreu, A.E.M. Beedle, A. Lezamiz, M. Uroz, A.J. Kosmalska, R. Oria, J.Z. Kechagia, P. Rico-Lastres, A.-L. Le Roux, C.M. Shanahan, X. Trepat, D. Navajas, S. Garcia-Manyes, and P. Roca-Cusachs
  • 1411 ➥ Ancestral Circuits for the Coordinated Modulation of Brain State ➥ by M. Lovett-Barron, A.S. Andalman, W.E. Allen, S. Vesuna, I. Kauvar, V.M. Burns, and K. Deisseroth
■ ■  THEORY ■ ■
■ ■  RESOURCES ■ ■
■ ■  ANNOUNCEMENTS ■ ■

■ ■  POSITIONS AVALABLE ■ ■

■ ■  ON THE COVER  ■ ■
  •  ➥ Immune evasion is a hallmark of cancer.  One mechanism of immune evasion involves disrupting the antigen presenting machinery.  In this issue of Cell, McGranahan et al. (1259-1271) presented LOHHLA (Loss of Heterozygosity in Human Leukocyte Antigen), a tool to systematically evaluate the prevalence and importance of HLA loss in cancer.  By applying this tool to analyze samples from patients with non-small-cell lung cancer, the authors demonstrated that HLA loss is a common subclonal mechanism of immune evasion, subject to strong selection pressures, and associated with an elevated mutation burden and immune activation.  The cover image shows a cell surface with HLA class I from both maternal and paternal lineages (in green and pink), presenting brigtly colored neoantigen peptides.  One of the parental HLA alleles is subject to loss, illustrated by the green HLA class I proteins gradually disappearing from the cell surface.  Cover artwork by Jeroen Claus with Phospho Biomedical Animation.

Origin: Cambridge, Massachusetts (MA)
Country: Printed in the USA / United States / U.S.A.
Condition: Like New!

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