| Hayden Panettiere | Claire Bennet (76 episodes, 2006-2010) | ||
| Jack Coleman | Noah Bennet (75 episodes, 2006-2010) | ||
| Milo Ventimiglia | Peter Petrelli (70 episodes, 2006-2010) | ||
| Masi Oka | Hiro Nakamura (66 episodes, 2006-2010) | ||
| Greg Grunberg | Matt Parkman (64 episodes, 2006-2010) | ||
| Ramamurthy | Mohinder Suresh (63 episodes, 2006-2010) | ||
| James Kyson | Ando Masahashi (63 episodes, 2006-2010) | ||
| Adrian Pasdar | Nathan Petrelli (61 episodes, 2006-2010) | ||
| Zachary Quinto | Sylar (61 episodes, 2006-2010) | ||
| Ali Larter | Niki Sanders / ... (58 episodes, 2006-2010) | ||
| Cristine Rose | Angela Petrelli (53 episodes, 2006-2010) | ||
| Ashley Crow | Sandra Bennet / ... (41 episodes, 2006-2010) | ||
| Jimmy Jean-Louis | The Haitian (32 episodes, 2006-2010) | ||