| Adam Sandler | Dracula (voice) | |
| Andy Samberg | Jonathan (voice) | |
| Selena Gomez | Mavis (voice) | |
| Kevin James | Frankenstein (voice) | |
| Steve Buscemi | Wayne (voice) | |
| David Spade | Griffin (voice) | |
| Keegan-Michael Key | Murray (voice) | |
| Asher Blinkoff | Dennis (voice) | |
| Fran Drescher | Eunice (voice) | |
| Molly Shannon | Wanda (voice) | |
| Megan Mullally | Grandma Linda (voice) | |
| Nick Offerman | Grandpa Mike (voice) | |
| Dana Carvey | Dana (voice) | |
| Rob Riggle | Bela (voice) | |
| Mel Brooks |