Dan Rayburn and Charlie Reed are best friends and co-owners of a successful sports marketing firm. Seven years prior, Dan, recently divorced, married Vicki after being whisked away by Charlie for a tropical vacation. The marriage, however, is short lived. Seven years later, Vicki resurfaces to tell him that their short marriage resulted in something he never suspected: twins Zach and Emily.
As Vicki is facing jail time for her work as an environmental activist, and her friend Jenna is hospitalized from a freak accident, she asks Dan to take care of the kids while she does her time. Thinking this might be his chance to get back with Vicki, Dan agrees, but only if Charlie helps him as neither have any experience taking care of kids. At the same time, they must finalize a huge marketing deal with a Japanese company, something they've always dreamed of, but will take all of their talents to clinch.
As Dan's condo does not allow children, they have to board with Charlie. Charlie and Dan's attempts to take care of the kids are well-intentioned, but very awkward. On a trip with the kids to an overnight camp, a hard-nosed camp instructor, Barry, becomes convinced that Dan and Charlie are homosexual partners. The trip ends after Dan accidentally sets a beloved statue of the camp's founder on fire.
The following have performed the puppets in Jimmy Lunchbox's show and are credited as "Muppets":