The Parker Thermostatic Expansion Valve 048227 is designed for use with R410A refrigerant. Specifically, it is compatible with the Parker brand and model HXCE. This expansion valve helps to regulate the refrigerant flow in a heating and cooling system, ensuring optimal performance and energy efficiency. It is important to note that this product is intended for professional use in HVAC and refrigeration systems, and should be installed by a certified technician. Additionally, it is important to follow the California Prop 65 Warning guidelines provided by the manufacturer.